PLK1 - Wikipedia
Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 (PLK-1) or serine/threonine-protein kinase 13 (STPK13), is an enzyme that in humans is encoded by the PLK1 (polo-like kinase 1) gene.
Polo-like kinase 1 (PLK1) signaling in cancer and beyond
PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle regulation and is expressed predominantly during the G2/S and M phase of the cell cycle. PLK1-mediated phosphorylation of specific substrates controls cell entry into mitosis, centrosome maturation, spindl …
Polo-like kinase 1 (PLK1) signaling in cancer and beyond
Nov 1, 2021 · PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle regulation and is expressed predominantly during the G2/S and M phase of the cell cycle.
PLK1 Gene - GeneCards | PLK1 Protein | PLK1 Antibody
Dec 10, 2024 · PLK1 (Polo Like Kinase 1) is a Protein Coding gene. Diseases associated with PLK1 include Gonococcal Keratitis and Polyploidy. Among its related pathways are Loss of proteins required for interphase microtubule organization from the centrosome and EML4 and NUDC in mitotic spindle formation.
Targeting polo-like kinase 1 for cancer therapy - Nature
Apr 1, 2006 · Human polo-like kinase 1 (PLK1) is essential during mitosis and in the maintenance of genomic stability. PLK1 is overexpressed in human tumours and has prognostic potential in cancer,...
PLK1 inhibition-based combination therapies for cancer …
In this review, we first discuss structure and function of PLK1, role of PLK1 in cancers, PLK1 specific inhibitors, and advantages of using combination therapy versus monotherapy followed by a critical account on PLK1-based combination therapies in cancer treatments, especially highlighting recent advancements and challenges.
Polo-like Kinase 1 Inhibitors in Human Cancer Therapy: …
Polo-like kinase 1 (PLK1) plays an important role in a variety of cellular functions, including the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal transition (EMT). PLK1 overexpression is often associated with cell proliferation and poor prognosis in cancer patients, making it a promising antitumor target.
PLK1 induces chromosomal instability and overrides cell cycle ...
Polo-like kinase 1 (PLK1) is an essential cell cycle regulator that is frequently overexpressed in various human cancers. To determine whether Plk1 overexpression drives tumorigenesis, we established transgenic mouse lines that ubiquitously express increased levels of Plk1.
Polo-like kinase 1 induces epithelial-to-mesenchymal transition and ...
Mar 22, 2016 · PLK1 overexpression promotes EMT and motility of prostate epithelial cells by upregulating ZEB proteins. We next sought to elucidate the signaling pathways downstream of oncogenic PLK1 that are responsible for the EMT induction …
Polo-like kinase 1 as target for cancer therapy
Dec 10, 2012 · Polo-like kinase 1 (Plk1) plays a critical role in cell division and represents a promising target for cancer therapy. Several small molecule inhibitors of polo-like kinase 1 have been described.