Apr 26, 2017 · Knowing this, how would you predict the relative basicity of nitriles, pyridine, and piperidine? By analogy to alkynes, we’d expect the lone pairs in sp-hybridized nitriles to be the …

May 7, 2018 · Electron withdrawing groups reduce basicity (and nucleophilicity), such as in morpholine versus piperidine (sigma acceptors) and acetamide (pi acceptor) versus …

Feb 16, 2004 · The reaction of benzylamine with the diiodo compound 6 in dioxane afforded the desired piperidine 7 in 97% yield. Deprotection of the amine gave the desired product 8. The …

Our earlier effort to develop constrained analogues of flexible piperidine analogs for monoamine transporters led to the development of a series of 3,6-disubstituted piperidine derivatives, and …

Oct 7, 2023 · Piperine encompasses a piperidine nucleus with antibacterial, anti-inflammatory, antihypertensive, anticonvulsant, antimalarial, antiviral, and anticancer properties. The current …

Successful cyclisation to the piperidine was achieved by firstly reacting ammonia in methanol with 105 followed by heating the intermediate obtained at reflux with sodium acetate in acetonitrile, …

The current review summarizes recent scientific literature on intra- and intermolecular reactions leading to the formation of various piperidine derivatives: substituted piperidines, …

May 28, 2014 · Piperidine and benzylamine provide exclusively β-adducts in respect to the aroyl keto group. Influence of the substituents of the aroyl phenyl ring of AACPs on the rate of the …

explain why amines are more basic than amides, and better nucleophiles. describe how an amine can be extracted from a mixture that also contains neutral compounds illustrating the reactions …

Apr 19, 2003 · The present results establish the newly developed 3,6-disubstituted piperidine derivatives as a novel template for high-affinity inhibitors of DAT. Structurally these molecules …