Adam’s current work focuses on the use of modular polymer design to study the biophysical basis of NLRP3 inflammasome activation. Using high throughput polymer synthesis and rational molecular design, we hope to create a library of polymers that activate inflammasomes to better understand the mechanism of polymer-induced lysosomal rupture.

Now, Adam is blending his interests in chemistry and immunology as a PhD student in chemistry co-advised by Aaron Esser-Kahn and Stuart Rowan. His current work focuses on the use of modular polymer design to study the biophysical basis of lysosomal rupture in NLRP3 inflammasome activation.

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Jul 8, 2024 · Working with UChicago’s Cellular Screening Center, Knight screened 2,000 small molecules on live cells and tested the level of cytokines produced by the immune cells. Cytokines are small proteins that, when released, signal the body’s immune system to get to work.

‪Scientist, Translational Immunology - Startup‬ - ‪‪Cited by 148‬‬ - ‪Vaccines‬ - ‪Immunology‬ - ‪Formulation‬ - ‪Drug Delivery‬ - ‪Polymers‬

Adam Weiss I am a rising 5th year graduate student in the Chemistry PhD program at University of Chicago co-advised by Aaron Esser-Kahn and Stuart Rowan and supported through an NIH T32 Chemistry Biology Interface training grant.

UChicago Expands IME to School of Molecular Engineering with $100 Million from Pritzkers chicagomaroon.com

Jul 8, 2024 · We identified over two dozen small molecules in several chemical classes that induce a training phe-notype in the absence of initial immune activation—a current limitation of reported inducers of training.