Mechanistically, FBXW7 binds to S6K1 and promotes its ubiquitination and proteasomal degradation, which in turn impacts glycolysis and brown preadipocyte proliferation via lactate. Besides, the ...
The mTOR pathway lies at the core of this amino-acid-sensing pathway (Fig. 4). It not only senses nutrient availability and intracellular energy status, but also integrates this information with ...
T administration had no effect on androgen receptor or 5α-reductase levels, nor on proteins involved in the mTORC1-signaling pathway (mTOR, S6K1, eEF2 and RPS6). Neither did it affect the abundance of ...
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