Nature22d
Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface
Newer agents may provide better specificity. Rapamycin inhibits the growth factor mTOR (mammalian target of rapamycin), which is activated by both physiological and pathological hypertrophy.
eLife3d
mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance
Crossing TRGL mice with a model of a neurodegenerative disease, the Q175 mouse model of HD, has enabled us to assess disease-related autophagy alterations in the Q175 and TRGL/Q175 models and their ...
The EMBO Journal29d
E3 ligase FBXW7 suppresses brown fat expansion and browning of white fat
Mechanistically, FBXW7 binds to S6K1 and promotes its ubiquitination and proteasomal degradation, which in turn impacts glycolysis and brown preadipocyte proliferation via lactate. Besides, the ...
BMJ22d
Cartilage-specific deletion of mTOR upregulates autophagy and protects mice from osteoarthritis
uhnresearch.ca Objectives Mammalian target of rapamycin (mTOR) (a serine/threonine protein kinase) is a major repressor of autophagy, a cell survival mechanism. The specific in vivo mechanism of mTOR ...
The EMBO Journal26d
RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Small GTPase RHEB is a well-known mTORC1 ...