Cellular senescence, where cells permanently stop dividing, plays a complex role in liver health. In a recent review article, ...

Gut microbiota-derived phenylacetylglutamine accelerates aging by driving cellular senescence through mitochondrial ...

In the right column, the protein detected (p21-Cre) is only expressed in senescent liver cells ... cause DNA damage in liver cells that causes them to go into senescence, a state in which cells are ...

Additionally, miR-449 overexpression activated p53 and its downstream target p21, along with the apoptosis markers Caspase 3 and Poly (ADP-Ribose) Polymerase (PARP). These observations indicated that ...

The senescence-associated markers p16, p21, p53 and beta galactosidase were induced upon drug treatment, and this was associated with increased lipid storage, increased expression of lipid ...

Furthermore, G6PD knockdown significantly increased the number of cells positive for SA-β-GAL (β-galactosidase) staining; the expression of p21, one classic marker for senescence, was upregulated in ...

Senescence is a normal response to a variety of cellular stressors. In a perfect world, senescence gives the body time to repair damage or eliminate the damaged cells before they're allowed to ...

Scientists at the University of California San Diego School of Medicine have uncovered a key mechanism explaining how liver cancer manages to develop despite the body’s natural defenses against tumor ...