Cell signaling pathways ... such as apoptosis and autophagy[5][6]. Research indicates that targeting these pathways, along with key proteins like AMP-activated protein kinase (AMPK) and SIRT1 ...

AMPK controls signaling pathways that postpone aging ... mitochondrial biogenesis, autophagy, mitohormesis, inflammation, and neurodegeneration. As a result, AMPK plays an important role in ...

Objective: Diabetic neuropathy (DN) is an important complication of diabetes mellitus. Autophagy is considered to be potentially involved in the regulation of DN. Metformin is broadly utilized in the ...

In OSCC, several signaling pathways influence the regulation of autophagy, dictating its dual roles in tumor suppression and progression. This section explores three key pathways—mTOR, AMPK, and ...

AMPK activation stimulates ULK1 phosphorylation, initiating autophagy while simultaneously inhibiting mTORC1. Conversely, mTORC1 can suppress autophagy by inhibiting both ULK1 and beclin-1 complexes.

The transcription factor sex-determining region Y-related high-mobility group-box gene 9 (SOX9) plays a critical role in ...

This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

"Some people may leave our platforms for virtue signaling, but I think the vast majority and many new users will find that these changes make the products better." Zuckerberg was replying to a ...

In conclusion, this work indicated that psychological stress may down-regulate the miR-335-3p expression, which resulted in the accumulation of FOS and the up-regulation of NFACT1 signaling pathway in ...

Department of Chemical Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India ...