The Colts are favorites to defeat the Jaguars, according to the BetMGM NFL odds. Not interested in this game? Check out expert picks and best bets for every NFL game this week. NFL STATS CENTRAL ...

Here is how the Horseshoe Huddle staff sees the Week 18 matchup between the Indianapolis Colts and Jacksonville Jaguars unfolding.

The Colts are favored by 3.5 points in the latest Colts vs. Jaguars odds, while the over/under is 44.5 points, per SportsLine consensus. Before entering any Jaguars vs. Colts picks, you'll want to ...

In a matchup of two division rivals, the Indianapolis Colts (7-9) will face off against the Jacksonville Jaguars (4-12). The Colts are the favorites, expected to win by at least a field goal but ...

Let’s take a look around the AFC South with an offseason preview for each of the Colts’ divisional opponents. Up first are ...

My Jaguars vs. Colts predictions are taking the underdogs on the road against the five-point spread. Find out more in my NFL picks for Sunday, January 5. Kickoff is set for 1:00 p.m. ET at Lucas ...

The Jacksonville Jaguars travel to the Indianapolis Colts on the final weekend of the season. The Times-Union staff predicts the Week 18 matchup.

The Jaguars beat the Colts 37-34 in Jacksonville on Oct. 6 ... Past performances do not guarantee success in the future and betting odds fluctuate from one minute to the next.