Using a selective dye that highlights acidic organelles, including lysosomes and late endosomes, they observed robust staining both in retreating axons and around the ensheathing Schwann cells in ...

In the PNS, one Schwann cell forms a single myelin sheath (Figure 1A). By contrast, in the CNS, the oligodendrocyte sends cell processes to myelinate multiple segments on many axons (Figure 2).

The Feltri lab research focused on adhesion between myelinating cells, axons and the extracellular matrix and the signals that promote myelination. One of their major efforts was the study of laminin ...