Reversing opioid overdoses in rats using a drug that does not enter the brain prevents the sudden and severe withdrawal symptoms associated with therapeutics that target the central nervous system.

[58] By far the most feared opioid-induced toxicity is respiratory depression. Respiratory depressive side effects comprise the majority of severe opioid adverse effects. Adverse outcomes from ...

BARDA's order of OPVEE comes some five months after Indivior announced the results from a pharmacodynamic study demonstrating ...

Scientists have revealed that opioid receptors outside the brain play a key role in the hypoventilation caused by fentanyl overdoses, paving the way for better treatments. The study, forthcoming ...

causing increased 911 call volume for opioid induced respiratory depression, altered levels of consciousness and deaths. The opioid heroin spiked in use in the United States from 373,000 yearly ...

A study conducted at Turku PET Centre in Finland showed that changes in the functioning of opioid neurotransmitters in the brain may underlie anorexia.

Opioids cross the placenta and may lead to respiratory depression and psycho-physiologic effects in neonates. Have an opioid antagonist (eg, naloxone) available for reversal of opioid induced ...

The individual and situational variability of respiratory depression caused by intravenous heroin is poorly understood. The aim of this study was to use advanced physiological monitoring to follow the ...

A new human-relevant model for studying multi-system pharmacodynamics and toxicity for opioids and opioid overdose treatment ...

concomitant drugs that cause respiratory depression). Opioid-induced hyperalgesia (OIH) and allodynia; consider reducing current opioid analgesic dose or rotating opioid if OIH is suspected.