In meningitis, the bacteria attack the lining around the brain called the meninges. They breach the ... It's a severe blood poisoning called meningococcal sepsis that affects the entire body.

They create a cushion between the brain and the cranium (skull) and the spinal cord and the vertebrae (spine). The meninges also provide structural support for important blood vessels and nerves ...

The infection can spread to the meninges, a protective layer of ... Things become most serious when the bacteria crosses the blood-brain barrier. This could mean more inflammation and swelling ...

The delivery challenge is posed by the blood–brain barrier (BBB), which prevents around 95% of small molecules, and almost all therapeutic biologics, from leaving the bloodstream and entering ...

More information: Wang, C., et al. Intravenous administration of blood-brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system, Nature Biotechnology (2024).