In 2021, a research team led by Prof. Heiko Lickert from Helmholtz Munich discovered the insulin-inhibitory receptor "Inceptor" and its role as a suppressor of the insulin signaling pathway.

One possibility is that in an attempt to overcome the inhibition within the metabolic insulin-signaling pathway, hyperinsulinemia may continue to stimulate the mitogenic insulin-signaling pathway ...

suggesting that insulin resistance occurred despite normal insulin signaling pathways. HFD-fed wild-type mice had elevated ...

In addition, there is evidence that in type 2 diabetes, the activation of these same pathways by elevations in glucose and free fatty acid (FFA) levels leads to both insulin resistance and ...

A spate of year-end collaborations highlights growing enthusiasm for expanding use of automated insulin delivery devices or ...

In worms and flies, the gene codes for a receptor protein that is activated by an "insulin-like" growth factor. This signaling pathway is analogous to the mammalian insulin pathway.

Together with his team, they discovered Inceptor in 2021 and described its role as an inhibitor of the insulin signaling pathway. Both Inceptor and the insulin receptor are located on the surface ...

Extensive Scientific Evidence Supporting Growth Factor Receptor Bound Protein-2 (Grb2) as Fundamental Link in Insulin ResistanceReallocates ...

Insulin resistance refers to impaired insulin ... This not only adds to our understanding of biology and signaling pathways in cells, but, more importantly, it is leading to exciting new ...

These metabolites were enriched in the valine, leucine, and isoleucine degradation pathway (P =.006), in which degradation ... EDS is associated with disordered glucose metabolism and insulin ...

But what are the exact genetic pathways that make South Asians more ... their pancreas which hinders the ability to produce enough insulin, and the unfavourable distribution of fat (lipodystrophy ...