The allele frequency represents the incidence of a gene variant in a population. Alleles are variant forms of a gene that are located at the same position, or genetic locus, on a chromosome.

Relative allele frequency is the percentage of all copies of a certain gene in a population that carry a specific allele. This is an accurate measurement of the amount of genetic variation in a ...

If PKU carriers were most likely to have children than non-carriers because of the protective effects of the PKU gene, over time, the disease-causing allele would increase the population.

2005;50(3):184-188. For example, in a white population, the most common deleterious allelic variant in the CFTR gene is CFTR delta F508 allele, resulting in the absence of a single amino acid ...

The height of pea plants is controlled by a single gene which has two alleles: tall and short. The tall allele is dominant and is shown as T. The small allele is recessive and is shown as t.

A gene known as HbS was the center of a medical and evolutionary detective story that began in the middle 1940s in Africa. Doctors noticed that patients who had sickle cell anemia, a serious ...

Along with long-range PCR for HLA genes, allele typing using NGS is an important immunodiagnostic method. PCR thermal cyclers are typically used for NGS sample preparation, including library ...