Recent studies have revealed that the JAK2 V617F mutation, typically associated with Ph-negative MPNs, can coexist with the BCR-ABL1 fusion gene in patients with CML. For instance, one study ...

The most common MPN to have this fusion gene is CML. The other five types of MPNs do not have BCR-ABL1. Most MPNs develop slowly and cause very few symptoms. You may not know you have any of these ...

chromosome in 1960 paved the way to identification of BCR/ABL as the principal genetic driver of CML. Another 45 years passed ...