AMPK signaling promotes an increase in cell stiffness that ... suggesting that these scavenging pathways require machinery from the autophagy pathway for function. Our lab and others have now made ...

Cell signaling pathways ... such as apoptosis and autophagy[5][6]. Research indicates that targeting these pathways, along with key proteins like AMP-activated protein kinase (AMPK) and SIRT1 ...

In OSCC, several signaling pathways influence the regulation of autophagy, dictating its dual roles in tumor suppression and progression. This section explores three key pathways—mTOR, AMPK, and ...

The process of autophagy is the main degradation pathway for mutant htt and various studies demonstrated ... we aimed to characterise AMPK as a new drug target for autophagy induction. In this regard, ...

Autophagy is regulated by key cell signaling pathways such as Akt (protein kinase B, PKB), mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK) involved in cell survival and ...

Objective: Diabetic neuropathy (DN) is an important complication of diabetes mellitus. Autophagy is considered to be potentially involved in the regulation of DN. Metformin is broadly utilized in the ...

AMPK controls signaling pathways that postpone aging ... mitochondrial biogenesis, autophagy, mitohormesis, inflammation, and neurodegeneration. As a result, AMPK plays an important role in ...